Pulmonary Hypertension Is Related to Peripheral Endothelial Dysfunction in Heart Failure With Preserved Ejection Fraction Farrero et al: Endothelium and Pulmonary Hypertension in HFpEF
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چکیده
B i p Med ed ed ed edicine De e ep par rt tm ment nt nt t t, Pn n neu u umo ol logy g gy, Abstract Background—Pulmonary hypertension and collagen metabolism abnormalities are
منابع مشابه
Pulmonary hypertension is related to peripheral endothelial dysfunction in heart failure with preserved ejection fraction.
BACKGROUND Pulmonary hypertension (PH) and collagen metabolism abnormalities are prevalent in patients with heart failure with preserved ejection fraction (HFpEF). Peripheral endothelial dysfunction (PED) has been described in HF and in pulmonary arterial hypertension. Our aim is to determine whether PH is associated with PED and impaired collagen metabolism in patients with HFpEF.; METHODS A...
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Patients with heart failure with preserved ejection fraction (HFpEF) have an increased mortality and morbidity similar to patients with systolic heart failure and reduced ejection fraction.1 The incidence of HFpEF is increasing,2 and roughly 30% to 50% of all patients with heart failure have a normal ejection fraction.3 The underlying pathophysiology is increased left ventricular diastolic stif...
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692 Heart failure with preserved ejection fraction (HFpEF) remains a common yet vexing clinical syndrome, with no approved therapies despite prevalence, morbidity, and mortality on a par with those of heart failure with reduced ejection fraction. Therapies and devices proven effective in heart failure with reduced ejection fraction have repeatedly fallen short in their application to HFpEF. Thi...
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Heart failure with preserved ejection fraction (HFpEF) currently accounts for 50 % of all HF patients, and its prevalence relative to HF with reduced EF (HFrEF) is rising at a rate of approximately 1 % per year [1,2]. Patients with HFpEF have a poor prognosis, with only slight lower mortality rates than patients with HFrEF [1,3]. According to current critera, HFpEF is diagnosed in the presence ...
متن کاملPhenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap.
Heart failure (HF) with preserved ejection fraction (EF; HFpEF) accounts for 50% of HF cases, and its prevalence relative to HF with reduced EF continues to rise. In contrast to HF with reduced EF, large trials testing neurohumoral inhibition in HFpEF failed to reach a positive outcome. This failure was recently attributed to distinct systemic and myocardial signaling in HFpEF and to diversity ...
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تاریخ انتشار 2014